Comparison of 2 enrichment results and further clustering
c_compareGT.Rmd
library(EnrichGT)
#> Loading required package: dplyr
#>
#> Attaching package: 'dplyr'
#> The following objects are masked from 'package:stats':
#>
#> filter, lag
#> The following objects are masked from 'package:base':
#>
#> intersect, setdiff, setequal, union
#> Loading required package: tibble
#> Loading required package: gt
#> Loading required package: cli
#>
#> ── EnrichGT ────────────────────────────────────────────────────────────────────
#> ℹ View your enrichment result by entring `EnrichGT(result)`
#> → by Zhiming Ye, https://github.com/ZhimingYe/EnrichGTEnrichment Result Comparing
clusterProfiler provides tools for comparing biological
functions (clusterProfiler::compareCluster()), but its
result granularity may not be detailed enough. Therefore, the
compareGT() function offers a way to perform a more
granular comparison between two specific enrichment results. The input
objects are two ORA or GSEA results from different sources.
Some important distinctions to note:
If you need to further enrich the results from
clusterProfiler::compareCluster(), simply pass them toEnrichGT(), which will automatically recognize the multi-group comparison results fromclusterProfiler, eliminating the need for thecompareGT()function. ThecompareGT()function serves a different purpose; you need to provide two independently sourced results.compareGT()is designed to yield more granular results, providing a more precise view of biological process differences, whileclusterProfiler::compareCluster()is suitable for multiple groups and provides a broader overview.compareGT()is limited to comparisons between only two groups.The primary focus of
compareGT()is on comparing enrichment results from heterogeneous gene sets of different sources. If you want to integrate enrichment results from the same source but across different databases, use alist()to contain the enrichment results, such asEnrichGT(list(a, b, c)).EnrichGTwill then automatically merge these results.
Generate Data Sets
suppressMessages({
library(tidyverse)
library(gt)
library(clusterProfiler)
library(org.Hs.eg.db)
})
data(geneList, package="DOSE")
gene_up <- names(geneList)[(geneList) > 1]
gene_down <- names(geneList)[(geneList) < (-1)]
ego_up <- enrichGO(gene = gene_up,
universe = names(geneList),
OrgDb = org.Hs.eg.db,
ont = "BP",
pAdjustMethod = "BH",
pvalueCutoff = 0.5,
qvalueCutoff = 0.5,
readable = TRUE)
ego_down <- enrichGO(gene = gene_down,
universe = names(geneList),
OrgDb = org.Hs.eg.db,
ont = "BP",
pAdjustMethod = "BH",
pvalueCutoff = 0.5,
qvalueCutoff = 0.5,
readable = TRUE)Run compareGT
dd<-compareGT(obj.test = ego_up,obj.ctrl = ego_down)
#> Loading required package: text2vec
#>
#> Attaching package: 'text2vec'
#> The following object is masked from 'package:BiocGenerics':
#>
#> normalize
The result is a list, with 4 Enrich_obj objects with
overlap and non-overlap gene sets in it.
str(dd,max.level = 2)
#> List of 4
#> $ Overlap_Control:Formal class 'EnrichGT_obj' [package "EnrichGT"] with 6 slots
#> $ Overlap_Test :Formal class 'EnrichGT_obj' [package "EnrichGT"] with 6 slots
#> $ Control_Only :Formal class 'EnrichGT_obj' [package "EnrichGT"] with 6 slots
#> $ Test_Only :Formal class 'EnrichGT_obj' [package "EnrichGT"] with 6 slotsResult Preview
Overlap(in control)
dd[["Overlap_Control"]]@gt_object| Parse form: Overlap_Control | ||||
| Split into 15 Clusters. Generated by github@zhimingye/EnrichGT | ||||
| Description | Count | PCT | Padj | geneID |
|---|---|---|---|---|
| Cluster_1 | ||||
|
extracellular matrix organization
GO:0030198
|
45 | 6.20 | 2.5e-07 | FBLN1, COL3A1, ANGPTL7, COL5A3, MMP10, COL5A2, OLFML2B, CTSK, TIE1, ADAMTS5, MMP2, COL7A1, GAS6, FAP, CST3, EMILIN1, CAV1, COL5A1, LAMA2, LOXL1, CRISPLD2, COL8A2, COLQ, LRP1, HPN, ECM2, AEBP1, POSTN, DPT, FMOD, LAMB2, TNFRSF11B, COL10A1, TPSAB1, COL4A5, ELN, COL14A1, RAMP2, COL16A1, MMP28, MYH11, COMP, COL17A1, MATN3, MFAP4 |
|
extracellular structure organization
GO:0043062
|
45 | 6.20 | 2.5e-07 | FBLN1, COL3A1, ANGPTL7, COL5A3, MMP10, COL5A2, OLFML2B, CTSK, TIE1, ADAMTS5, MMP2, COL7A1, GAS6, FAP, CST3, EMILIN1, CAV1, COL5A1, LAMA2, LOXL1, CRISPLD2, COL8A2, COLQ, LRP1, HPN, ECM2, AEBP1, POSTN, DPT, FMOD, LAMB2, TNFRSF11B, COL10A1, TPSAB1, COL4A5, ELN, COL14A1, RAMP2, COL16A1, MMP28, MYH11, COMP, COL17A1, MATN3, MFAP4 |
|
external encapsulating structure organization
GO:0045229
|
45 | 6.20 | 2.5e-07 | FBLN1, COL3A1, ANGPTL7, COL5A3, MMP10, COL5A2, OLFML2B, CTSK, TIE1, ADAMTS5, MMP2, COL7A1, GAS6, FAP, CST3, EMILIN1, CAV1, COL5A1, LAMA2, LOXL1, CRISPLD2, COL8A2, COLQ, LRP1, HPN, ECM2, AEBP1, POSTN, DPT, FMOD, LAMB2, TNFRSF11B, COL10A1, TPSAB1, COL4A5, ELN, COL14A1, RAMP2, COL16A1, MMP28, MYH11, COMP, COL17A1, MATN3, MFAP4 |
|
regulation of hormone levels
GO:0010817
|
58 | 8.00 | 1.2e-04 | AQP1, SHH, ALDH1A1, GHRH, CYP26A1, BBS1, DIO1, LEP, ADH1C, HSD17B4, CTSK, PER2, INHBB, CCN3, SREBF1, ESR1, IGF1R, DDO, ABCC8, LIPE, CYP21A2, GHR, GABBR1, CPE, SLC18A2, BAIAP3, SLC7A8, AFP, PCSK5, HPN, WNT4, RAPGEF4, PNPLA4, F2RL2, SYBU, GJA1, AGTR1, ANO1, CPA3, DHRS2, IRS1, UCN, CARTPT, ADRA2A, TBX3, C1QTNF3, ABAT, ADIPOQ, MYRIP, ITPR1, CORIN, ADH1B, FOXA1, CRY2, GRP, STC2, GATA3, TFAP2B |
|
multi-organism reproductive process
GO:0044703
|
27 | 3.70 | 7.4e-03 | FBLN1, THBD, IGFBP2, LEP, PRLR, TPPP3, MMP2, ESR1, PTN, DDO, ABCC8, HSPG2, MAGED2, PCSK5, WNT4, PTHLH, GJA1, TGFB3, TAC1, AR, UCN, ADRA2A, COL16A1, CORIN, NDP, STC2, PGR |
|
female pregnancy
GO:0007565
|
25 | 3.40 | 7.5e-03 | FBLN1, THBD, IGFBP2, LEP, PRLR, TPPP3, MMP2, ESR1, PTN, ABCC8, HSPG2, MAGED2, PCSK5, WNT4, PTHLH, GJA1, TGFB3, AR, UCN, ADRA2A, COL16A1, CORIN, NDP, STC2, PGR |
|
multi-multicellular organism process
GO:0044706
|
27 | 3.70 | 9.5e-03 | FBLN1, THBD, IGFBP2, LEP, PRLR, TPPP3, MMP2, ESR1, PTN, DDO, ABCC8, HSPG2, MAGED2, PCSK5, WNT4, PTHLH, GJA1, TGFB3, TAC1, AR, UCN, ADRA2A, COL16A1, CORIN, NDP, STC2, PGR |
|
collagen metabolic process
GO:0032963
|
17 | 2.30 | 9.7e-03 | PCOLCE, MMP10, CTSK, MMP2, P3H3, FAP, CST3, EMILIN1, COL5A1, CBX8, WNT4, TGFB3, UCN, TNS2, MMP28, BMP4, MFAP4 |
|
hormone metabolic process
GO:0042445
|
28 | 3.90 | 1.3e-02 | SHH, ALDH1A1, CYP26A1, BBS1, DIO1, LEP, ADH1C, HSD17B4, CTSK, ESR1, IGF1R, DDO, LIPE, CYP21A2, GHR, CPE, AFP, PCSK5, HPN, WNT4, PNPLA4, CPA3, DHRS2, CORIN, ADH1B, FOXA1, STC2, GATA3 |
|
fat cell differentiation
GO:0045444
|
27 | 3.70 | 1.8e-02 | LPL, BBS1, UCP1, WNT5B, LEP, BBS4, FTO, PER2, MSX2, INHBB, SREBF1, XBP1, RORC, ZNF516, ZBTB16, TGFB1I1, ZFPM2, ENPP1, PEX11A, FRZB, TPH1, C1QTNF3, ADIPOQ, FABP4, TFAP2B, STEAP4, ADIRF |
| Cluster_2 | ||||
|
connective tissue development
GO:0061448
|
43 | 5.90 | 2.9e-07 | COL3A1, LPL, CYTL1, BBS1, TRPS1, WNT5B, LEP, BBS4, CTSK, FTO, MSX2, SORL1, EFEMP1, SCIN, CCN3, XBP1, RORC, WNT11, PDGFRB, CRIP1, COL5A1, OSR2, GHR, FGF18, ZNF516, ZBTB16, BGN, MSX1, BMPR1B, GLI3, PTHLH, EVC, FRZB, DLX2, ZEB1, PDGFD, COMP, BMP4, MATN3, HMGCS2, FOXA1, GATA3, OGN |
|
transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007178
|
45 | 6.20 | 1.8e-05 | APPL2, SHH, NBL1, NUMA1, COL3A1, FUT8, RASL11B, FSTL1, OVOL2, CIDEA, TMEM100, CRIM1, MSX2, SORL1, INHBB, CHRDL1, FST, ITGB5, CCN3, GAS6, EMILIN1, LTBP2, TGFB1I1, LRP1, AFP, MSX1, BMPR1B, LRRC32, HTRA1, FMOD, TGFB3, ZEB1, MAGI2, FBN1, TGFBR3, CLDN5, SFRP4, ZNF423, COMP, BMP4, LRP2, CILP, NDP, ASPN, TFAP2B |
|
skeletal system development
GO:0001501
|
56 | 7.70 | 1.4e-04 | IFT140, SHH, COL3A1, CYTL1, BBS1, COL5A2, WDR19, TRPS1, WNT5B, LEP, CTSK, MSX2, CDH11, EFEMP1, MMP2, PDGFC, FST, SCIN, CCN3, WNT11, MYOC, VCAN, OSR2, PLXNB1, EDNRA, GHR, FGF18, ZBTB16, DYNC2I1, PCSK5, BGN, MSX1, BMPR1B, GLI3, PTHLH, EVC, FRZB, DLX2, GJA1, TNN, TGFB3, ZEB1, TNFRSF11B, COL10A1, FBN1, TBX3, IGF1, SFRP4, SIGLEC15, COMP, BMP4, MATN3, CHAD, LRRC17, GATA3, OGN |
|
cartilage development
GO:0051216
|
30 | 4.10 | 2.0e-04 | COL3A1, CYTL1, BBS1, TRPS1, WNT5B, LEP, CTSK, MSX2, EFEMP1, SCIN, CCN3, WNT11, OSR2, GHR, FGF18, ZBTB16, BGN, MSX1, BMPR1B, GLI3, PTHLH, EVC, FRZB, DLX2, ZEB1, COMP, BMP4, MATN3, GATA3, OGN |
|
bone development
GO:0060348
|
27 | 3.70 | 5.1e-03 | COL3A1, LEP, MSX2, PDGFC, MYOC, OSR2, PLXNB1, GHR, FGF18, ZBTB16, BGN, MSX1, BMPR1B, GLI3, EVC, GJA1, TNN, TGFB3, FBN1, IGF1, SFRP4, SIGLEC15, COMP, BMP4, CHAD, LRRC17, OGN |
|
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090092
|
29 | 4.00 | 6.9e-03 | SHH, NBL1, NUMA1, RASL11B, FSTL1, CIDEA, CRIM1, MSX2, SORL1, CHRDL1, FST, CCN3, EMILIN1, TGFB1I1, LRP1, MSX1, HTRA1, TGFB3, ZEB1, MAGI2, FBN1, TGFBR3, SFRP4, ZNF423, BMP4, LRP2, CILP, ASPN, TFAP2B |
|
response to BMP
GO:0071772
|
21 | 2.90 | 7.5e-03 | NBL1, NUMA1, FSTL1, TMEM100, CRIM1, MSX2, SORL1, CHRDL1, FST, MSX1, BMPR1B, HTRA1, FBN1, TGFBR3, SFRP4, ZNF423, COMP, BMP4, LRP2, GATA3, TFAP2B |
|
cellular response to BMP stimulus
GO:0071773
|
21 | 2.90 | 7.5e-03 | NBL1, NUMA1, FSTL1, TMEM100, CRIM1, MSX2, SORL1, CHRDL1, FST, MSX1, BMPR1B, HTRA1, FBN1, TGFBR3, SFRP4, ZNF423, COMP, BMP4, LRP2, GATA3, TFAP2B |
|
BMP signaling pathway
GO:0030509
|
20 | 2.80 | 7.5e-03 | NBL1, NUMA1, FSTL1, TMEM100, CRIM1, MSX2, SORL1, CHRDL1, FST, MSX1, BMPR1B, HTRA1, FBN1, TGFBR3, SFRP4, ZNF423, COMP, BMP4, LRP2, TFAP2B |
|
regulation of BMP signaling pathway
GO:0030510
|
16 | 2.20 | 7.9e-03 | NBL1, NUMA1, FSTL1, CRIM1, MSX2, SORL1, CHRDL1, FST, MSX1, HTRA1, FBN1, SFRP4, ZNF423, BMP4, LRP2, TFAP2B |
| Cluster_3 | ||||
|
negative regulation of locomotion
GO:0040013
|
42 | 5.80 | 1.2e-04 | NAV3, SHH, PTPRG, NBL1, FBLN1, COL3A1, IL33, SEMA5A, TIE1, MMRN2, CDH11, CCN3, WNT11, CXCL12, ABCC8, SEMA3G, EMILIN1, SEMA3C, MACIR, RHOB, BMERB1, LRP1, WNT4, STARD13, NISCH, MEOX2, APOD, ALOX15B, GJA1, TNN, MAGI2, EVL, DCN, CLDN5, SEMA3E, ADIPOQ, DACH1, MMP28, BMP4, CX3CR1, GATA3, PTPRT |
|
negative regulation of cell motility
GO:2000146
|
38 | 5.20 | 3.1e-04 | NAV3, SHH, PTPRG, NBL1, FBLN1, COL3A1, IL33, TIE1, MMRN2, CDH11, CCN3, WNT11, CXCL12, ABCC8, EMILIN1, MACIR, RHOB, BMERB1, LRP1, WNT4, STARD13, NISCH, MEOX2, APOD, ALOX15B, GJA1, TNN, MAGI2, EVL, DCN, CLDN5, ADIPOQ, DACH1, MMP28, BMP4, CX3CR1, GATA3, PTPRT |
|
negative regulation of cell migration
GO:0030336
|
36 | 5.00 | 6.5e-04 | NAV3, SHH, PTPRG, NBL1, COL3A1, IL33, TIE1, MMRN2, CDH11, CCN3, WNT11, CXCL12, ABCC8, EMILIN1, MACIR, RHOB, BMERB1, LRP1, WNT4, STARD13, NISCH, MEOX2, APOD, ALOX15B, GJA1, TNN, MAGI2, EVL, DCN, CLDN5, ADIPOQ, DACH1, MMP28, BMP4, CX3CR1, PTPRT |
| Cluster_4 | ||||
|
blood circulation
GO:0008015
|
52 | 7.20 | 3.7e-03 | MYOF, TRPC1, KL, LEP, BBS4, KCND2, GSTM2, KCNMA1, PER2, ATP1A2, MMP2, SGCD, SREBF1, GAS6, CXCL12, NEDD4L, ABCC8, EMILIN1, CAV1, CACNA1C, CORO2B, EDNRA, PDE2A, GPD1L, PCSK5, PLN, NTS, POSTN, SCN3B, NPY1R, GJA1, AKAP12, AGTR1, HTR2B, CPA3, AR, UCN, CYP4F12, CARTPT, ADRA2A, CLDN5, SLC1A1, FXYD1, ELN, ABAT, RAMP2, CACNA1D, ADIPOQ, VSTM4, CORIN, KCNE4, COMP |
| Cluster_5 | ||||
|
insulin-like growth factor receptor signaling pathway
GO:0048009
|
11 | 1.50 | 1.4e-02 | GHRH, IGFBP2, IGFBP6, CRIM1, IGF1R, GHR, IGFBP4, AR, IRS1, IGF1, CILP |
|
regulation of insulin-like growth factor receptor signaling pathway
GO:0043567
|
7 | 0.96 | 1.8e-02 | GHRH, IGFBP2, IGFBP6, IGFBP4, AR, IGF1, CILP |
|
cellular response to amino acid stimulus
GO:0071230
|
12 | 1.70 | 4.3e-02 | COL3A1, COL5A2, MMP2, PDGFC, SH3BP4, XBP1, SESN1, NTRK2, ZEB1, PDGFD, COL16A1, HMGCS2 |
|
mammary gland alveolus development
GO:0060749
|
6 | 0.83 | 5.0e-02 | SOCS2, PRLR, ESR1, AR, TPH1, ERBB4 |
|
mammary gland lobule development
GO:0061377
|
6 | 0.83 | 5.0e-02 | SOCS2, PRLR, ESR1, AR, TPH1, ERBB4 |
| Cluster_6 | ||||
|
gland morphogenesis
GO:0022612
|
18 | 2.50 | 1.8e-02 | SHH, MSX2, MMP2, XBP1, ESR1, PTN, CAV1, CRIP1, SEMA3C, HPN, WNT4, GLI3, TGFB3, AR, TBX3, BMP4, FOXA1, PGR |
|
mammary gland development
GO:0030879
|
18 | 2.50 | 2.9e-02 | SOCS2, PRLR, MSX2, XBP1, ESR1, CAV1, MSX1, WNT4, GLI3, TGFB3, CDO1, AR, TBX3, TPH1, BMP4, ERBB4, GATA3, PGR |
|
prostate gland morphogenesis
GO:0060512
|
7 | 0.96 | 4.7e-02 | SHH, MMP2, ESR1, CRIP1, AR, BMP4, FOXA1 |
| Cluster_7 | ||||
|
hormone transport
GO:0009914
|
33 | 4.50 | 2.5e-02 | AQP1, GHRH, LEP, PER2, INHBB, CCN3, SREBF1, ABCC8, GABBR1, CPE, SLC18A2, BAIAP3, SLC7A8, RAPGEF4, F2RL2, SYBU, GJA1, AGTR1, ANO1, IRS1, UCN, CARTPT, ADRA2A, TBX3, C1QTNF3, ABAT, ADIPOQ, MYRIP, ITPR1, CRY2, GRP, GATA3, TFAP2B |
|
hormone secretion
GO:0046879
|
32 | 4.40 | 2.7e-02 | AQP1, GHRH, LEP, PER2, INHBB, CCN3, SREBF1, ABCC8, GABBR1, CPE, SLC18A2, BAIAP3, RAPGEF4, F2RL2, SYBU, GJA1, AGTR1, ANO1, IRS1, UCN, CARTPT, ADRA2A, TBX3, C1QTNF3, ABAT, ADIPOQ, MYRIP, ITPR1, CRY2, GRP, GATA3, TFAP2B |
|
signal release
GO:0023061
|
43 | 5.90 | 3.5e-02 | AQP1, GHRH, STXBP1, MYOF, LEP, PER2, CADPS2, INHBB, CCN3, SREBF1, CXCL12, ABCC8, GABBR1, CPE, SLC18A2, BAIAP3, PCSK5, RAPGEF4, SYT1, F2RL2, SYBU, SLC4A8, GJA1, AGTR1, ANO1, IRS1, UCN, WLS, CARTPT, ADRA2A, TBX3, C1QTNF3, ABAT, MAOB, ADIPOQ, MYRIP, ITPR1, SYT17, SLC44A4, CRY2, GRP, GATA3, TFAP2B |
|
regulation of hormone secretion
GO:0046883
|
27 | 3.70 | 4.3e-02 | GHRH, LEP, PER2, INHBB, CCN3, SREBF1, ABCC8, GABBR1, BAIAP3, RAPGEF4, F2RL2, SYBU, GJA1, AGTR1, ANO1, IRS1, UCN, CARTPT, ADRA2A, C1QTNF3, ABAT, ADIPOQ, MYRIP, ITPR1, CRY2, GRP, TFAP2B |
|
regulation of peptide hormone secretion
GO:0090276
|
22 | 3.00 | 4.3e-02 | GHRH, LEP, PER2, INHBB, CCN3, SREBF1, ABCC8, GABBR1, BAIAP3, RAPGEF4, F2RL2, SYBU, ANO1, IRS1, UCN, CARTPT, ADRA2A, ABAT, MYRIP, ITPR1, GRP, TFAP2B |
|
regulation of peptide secretion
GO:0002791
|
22 | 3.00 | 4.8e-02 | GHRH, LEP, PER2, INHBB, CCN3, SREBF1, ABCC8, GABBR1, BAIAP3, RAPGEF4, F2RL2, SYBU, ANO1, IRS1, UCN, CARTPT, ADRA2A, ABAT, MYRIP, ITPR1, GRP, TFAP2B |
|
regulation of peptide transport
GO:0090087
|
22 | 3.00 | 5.0e-02 | GHRH, LEP, PER2, INHBB, CCN3, SREBF1, ABCC8, GABBR1, BAIAP3, RAPGEF4, F2RL2, SYBU, ANO1, IRS1, UCN, CARTPT, ADRA2A, ABAT, MYRIP, ITPR1, GRP, TFAP2B |
| Cluster_8 | ||||
|
sensory organ morphogenesis
GO:0090596
|
28 | 3.90 | 2.5e-02 | AQP1, MFAP5, COL5A2, WDR19, BBS4, EFEMP1, LRIG1, COL5A1, OSR2, DZANK1, EDNRA, COL8A2, NTRK2, MSX1, HPN, GLI3, MYO6, FRZB, ZEB1, FBN1, TBX3, SLC1A1, TENM3, BMP4, SLC44A4, NDP, GATA3, TFAP2B |
|
tissue homeostasis
GO:0001894
|
28 | 3.90 | 3.3e-02 | ALDH1A1, COL3A1, JAM3, CYTL1, BBS1, BBS4, CTSK, ABCC8, LAMA2, IL20RA, TFF3, SPATA7, ALB, OPRPN, GJA1, LDB2, TNFRSF11B, CARTPT, AZGP1, MAK, CLDN5, TFF1, SLC1A1, SIGLEC15, VSTM4, COMP, NDP, PIP |
|
anatomical structure homeostasis
GO:0060249
|
28 | 3.90 | 3.3e-02 | ALDH1A1, COL3A1, JAM3, CYTL1, BBS1, BBS4, CTSK, ABCC8, LAMA2, IL20RA, TFF3, SPATA7, ALB, OPRPN, GJA1, LDB2, TNFRSF11B, CARTPT, AZGP1, MAK, CLDN5, TFF1, SLC1A1, SIGLEC15, VSTM4, COMP, NDP, PIP |
|
sensory system development
GO:0048880
|
36 | 5.00 | 4.7e-02 | AQP1, IFT140, SHH, MFAP5, ANGPTL7, COL5A2, WDR19, WNT5B, BBS4, EFEMP1, CHRDL1, PDGFRB, COL5A1, CACNA1C, OSR2, DZANK1, COL8A2, NTRK2, BMPR1B, GLI3, MAB21L1, DLX2, MEIS3P1, LAMB2, ZEB1, SALL2, FBN1, KERA, SLC1A1, TENM3, VSTM4, BMP4, SLC44A4, NDP, GATA3, TFAP2B |
|
cilium assembly
GO:0060271
|
28 | 3.90 | 4.8e-02 | ZMYND10, PCM1, IFT140, PARVA, KIF24, NME8, CEP162, BBS1, WDR19, DNAI4, BBOF1, BBS4, ALPK1, TOGARAM1, MACIR, DYNC2H1, PIERCE1, DYNC2I1, TTC12, CPLANE1, NISCH, SPAG6, EHD2, NME5, JHY, MAK, ABLIM3, CFAP69 |
|
eye development
GO:0001654
|
35 | 4.80 | 5.0e-02 | AQP1, IFT140, SHH, MFAP5, ANGPTL7, COL5A2, WDR19, WNT5B, BBS4, EFEMP1, CHRDL1, PDGFRB, COL5A1, CACNA1C, OSR2, DZANK1, COL8A2, NTRK2, BMPR1B, GLI3, MAB21L1, DLX2, MEIS3P1, LAMB2, ZEB1, SALL2, FBN1, KERA, SLC1A1, TENM3, VSTM4, BMP4, NDP, GATA3, TFAP2B |
| Cluster_9 | ||||
|
angiogenesis
GO:0001525
|
49 | 6.70 | 2.9e-02 | AQP1, CDH13, JCAD, SHH, ACKR3, PARVA, CALCRL, JAM3, OVOL2, PLXDC1, SEMA5A, LEP, TIE1, TMEM100, MMRN2, THBS2, MMP2, PLK2, CCN3, XBP1, FAP, ABCC8, PDGFRB, EMILIN1, CAV1, HSPG2, RHOB, EDNRA, ANPEP, FGF18, SPARC, COL8A2, STARD13, MEOX2, APOD, F3, TNN, AGTR1, ADGRB2, DCN, THBS4, CLDN5, SEMA3E, VAV3, RAMP2, VSTM4, BMP4, NDP, CX3CR1 |
Overlap(in Test group)
dd[["Overlap_Test"]]@gt_object| Parse form: Overlap_Test | ||||
| Split into 15 Clusters. Generated by github@zhimingye/EnrichGT | ||||
| Description | Count | PCT | Padj | geneID |
|---|---|---|---|---|
| Cluster_1 | ||||
|
chromosome segregation
GO:0007059
|
63 | 12.00 | 1.5e-21 | CDCA8, CDC20, KIF23, CENPE, MYBL2, CCNB2, NDC80, TOP2A, NCAPH, ASPM, DLGAP5, UBE2C, HJURP, SKA1, NUSAP1, TPX2, TACC3, NEK2, CENPM, CENPN, CDK1, MAD2L1, KIF18A, CDT1, BIRC5, KIF11, TTK, NCAPG, AURKB, TRIP13, PRC1, KIFC1, KIF18B, AURKA, CCNB1, KIF4A, PTTG1, KIF14, KIF2C, CDC6, PLK1, RACGAP1, PTTG3P, BUB1B, ZWINT, CENPU, SPC25, SPAG5, ECT2, CENPI, ESPL1, CCNE1, OIP5, MKI67, HAUS6, CCNE2, GPSM2, NCAPD2, BUB1, STIL, CENPF, FBXO5, ZWILCH |
|
chromosome organization
GO:0051276
|
77 | 15.00 | 1.5e-21 | CDC45, CDCA8, CDC20, KIF23, CENPE, MYBL2, NDC80, TOP2A, NCAPH, DLGAP5, UBE2C, HJURP, NUSAP1, TPX2, TACC3, NEK2, CENPN, CDK1, MAD2L1, GINS1, KIF18A, CDT1, BIRC5, KIF11, EZH2, TTK, NCAPG, AURKB, GINS2, TRIP13, PRC1, KIFC1, KIF18B, CCNB1, KIF4A, MCM5, PTTG1, MCM2, KIF14, KIF2C, CDC6, PLK1, RACGAP1, PTTG3P, BUB1B, EXO1, ZWINT, SPC25, SPAG5, HMGA1, DSCC1, CENPI, RAD54L, ESPL1, RAD51, CCNE1, HMGB3, OIP5, CCNE2, MCM6, MCM4, FEN1, CCT5, RFC4, NCAPD2, CENPA, GINS4, BUB1, MYC, CENPF, PCNA, GINS3, RECQL4, FBXO5, ZWILCH, BLM, DNA2 |
|
nuclear chromosome segregation
GO:0098813
|
53 | 11.00 | 1.1e-20 | CDCA8, CDC20, KIF23, CENPE, MYBL2, CCNB2, NDC80, TOP2A, NCAPH, ASPM, DLGAP5, UBE2C, NUSAP1, TPX2, TACC3, NEK2, CDK1, MAD2L1, KIF18A, CDT1, BIRC5, KIF11, TTK, NCAPG, AURKB, TRIP13, PRC1, KIFC1, KIF18B, AURKA, CCNB1, KIF4A, PTTG1, KIF14, KIF2C, CDC6, PLK1, RACGAP1, PTTG3P, BUB1B, ZWINT, SPC25, SPAG5, ECT2, CENPI, ESPL1, CCNE1, CCNE2, NCAPD2, BUB1, CENPF, FBXO5, ZWILCH |
|
nuclear division
GO:0000280
|
61 | 12.00 | 5.3e-20 | CDCA8, CDC20, KIF23, CENPE, MYBL2, CCNB2, NDC80, TOP2A, NCAPH, ASPM, DLGAP5, UBE2C, NUSAP1, TPX2, NEK2, RAD51AP1, UBE2S, CDK1, MAD2L1, KIF18A, CDT1, BIRC5, KIF11, TTK, NCAPG, AURKB, CHEK1, TRIP13, PRC1, KIFC1, KIF18B, AURKA, CCNB1, KIF4A, PTTG1, KIF14, CKS2, KIF2C, MYBL1, PLK1, RACGAP1, PTTG3P, BUB1B, ZWINT, SPC25, SPAG5, CENPI, RAD54L, ESPL1, RAD51, CCNE1, MKI67, CCNE2, FANCA, TDRD12, CDC25B, NCAPD2, BUB1, CENPF, FBXO5, ZWILCH |
|
mitotic sister chromatid segregation
GO:0000070
|
42 | 8.30 | 5.3e-20 | CDCA8, CDC20, KIF23, CENPE, MYBL2, NDC80, NCAPH, DLGAP5, UBE2C, NUSAP1, TPX2, NEK2, CDK1, MAD2L1, KIF18A, CDT1, BIRC5, KIF11, TTK, NCAPG, AURKB, TRIP13, PRC1, KIFC1, KIF18B, CCNB1, KIF4A, KIF14, KIF2C, PLK1, RACGAP1, BUB1B, ZWINT, SPC25, SPAG5, CENPI, ESPL1, NCAPD2, BUB1, CENPF, FBXO5, ZWILCH |
|
sister chromatid segregation
GO:0000819
|
45 | 8.90 | 3.5e-19 | CDCA8, CDC20, KIF23, CENPE, MYBL2, NDC80, TOP2A, NCAPH, DLGAP5, UBE2C, NUSAP1, TPX2, TACC3, NEK2, CDK1, MAD2L1, KIF18A, CDT1, BIRC5, KIF11, TTK, NCAPG, AURKB, TRIP13, PRC1, KIFC1, KIF18B, CCNB1, KIF4A, KIF14, KIF2C, CDC6, PLK1, RACGAP1, BUB1B, ZWINT, SPC25, SPAG5, CENPI, ESPL1, NCAPD2, BUB1, CENPF, FBXO5, ZWILCH |
|
organelle fission
GO:0048285
|
63 | 12.00 | 3.5e-19 | CDCA8, CDC20, KIF23, CENPE, MYBL2, CCNB2, NDC80, TOP2A, NCAPH, ASPM, DLGAP5, UBE2C, NUSAP1, TPX2, NEK2, RAD51AP1, UBE2S, CDK1, MAD2L1, KIF18A, CDT1, BIRC5, KIF11, TTK, NCAPG, AURKB, CHEK1, TRIP13, PRC1, KIFC1, KIF18B, AURKA, CCNB1, KIF4A, PTTG1, KIF14, CKS2, KIF2C, MYBL1, PLK1, RACGAP1, PTTG3P, BUB1B, ZWINT, SPC25, SPAG5, CENPI, RAD54L, ESPL1, RAD51, CCNE1, MKI67, CCNE2, FANCA, TDRD12, CDC25B, NCAPD2, BUB1, CENPF, FBXO5, ZWILCH, MTFR1, RALA |
|
cell division
GO:0051301
|
72 | 14.00 | 7.3e-18 | CDCA8, CDC20, KIF23, CENPE, CCNB2, NDC80, TOP2A, NCAPH, E2F8, ASPM, CEP55, UBE2C, SKA1, NUSAP1, CDCA3, TPX2, TACC3, NEK2, UBE2S, CCNA2, CDK1, ERCC6L, MAD2L1, PAX6, CDT1, BIRC5, KIF11, NCAPG, AURKB, PRC1, KIFC1, KIF18B, KIF20A, AURKA, CCNB1, KIF4A, PTTG1, KIF14, CKS2, KIF2C, CDC25A, CDC6, PLK1, RACGAP1, BUB1B, ZWINT, SPC25, SPAG5, ECT2, ESPL1, CCNE1, OIP5, HELLS, CKS1B, HAUS6, CCNE2, GPSM2, TIPIN, TDRD12, CDC25B, NCAPD2, CENPA, PIMREG, BUB1, MYC, CENPF, FBXO5, ZWILCH, BLM, CDC123, RALA, STMN1 |
|
mitotic nuclear division
GO:0140014
|
46 | 9.10 | 1.9e-16 | CDCA8, CDC20, KIF23, CENPE, MYBL2, NDC80, NCAPH, DLGAP5, UBE2C, NUSAP1, TPX2, NEK2, UBE2S, CDK1, MAD2L1, KIF18A, CDT1, BIRC5, KIF11, TTK, NCAPG, AURKB, CHEK1, TRIP13, PRC1, KIFC1, KIF18B, AURKA, CCNB1, KIF4A, KIF14, KIF2C, PLK1, RACGAP1, BUB1B, ZWINT, SPC25, SPAG5, CENPI, ESPL1, MKI67, NCAPD2, BUB1, CENPF, FBXO5, ZWILCH |
|
regulation of chromosome segregation
GO:0051983
|
29 | 5.80 | 1.3e-13 | CDCA8, CDC20, CENPE, NDC80, NCAPH, DLGAP5, UBE2C, TACC3, CDK1, MAD2L1, BIRC5, TTK, NCAPG, AURKB, TRIP13, CCNB1, KIF2C, CDC6, PLK1, BUB1B, ZWINT, SPC25, ESPL1, MKI67, NCAPD2, BUB1, CENPF, FBXO5, ZWILCH |
| Cluster_2 | ||||
|
chemokine-mediated signaling pathway
GO:0070098
|
17 | 3.40 | 3.7e-06 | CXCL10, CXCL13, CXCL11, CXCL9, CCL18, CCL8, CXCL3, CCL20, CXCL8, CCL5, CXCR6, CCR1, CCL2, PADI2, CCL4, CCR8, CCR7 |
|
response to chemokine
GO:1990868
|
17 | 3.40 | 1.2e-05 | CXCL10, CXCL13, CXCL11, CXCL9, CCL18, CCL8, CXCL3, CCL20, CXCL8, CCL5, CXCR6, CCR1, CCL2, PADI2, CCL4, CCR8, CCR7 |
|
cellular response to chemokine
GO:1990869
|
17 | 3.40 | 1.2e-05 | CXCL10, CXCL13, CXCL11, CXCL9, CCL18, CCL8, CXCL3, CCL20, CXCL8, CCL5, CXCR6, CCR1, CCL2, PADI2, CCL4, CCR8, CCR7 |
|
neutrophil chemotaxis
GO:0030593
|
16 | 3.20 | 7.7e-05 | S100A9, S100A8, CXCL10, CXCL13, CXCL11, CXCL9, CCL18, CCL8, CXCL3, CCL20, CXCL8, CCL5, TREM1, CCL2, CCL4, CCR7 |
|
lymphocyte chemotaxis
GO:0048247
|
11 | 2.20 | 1.2e-04 | S100A7, CXCL10, CXCL13, CXCL11, CCL18, CCL8, CCL20, CCL5, CCL2, PADI2, CCL4 |
|
monocyte chemotaxis
GO:0002548
|
12 | 2.40 | 1.5e-04 | S100A7, CXCL10, CCL18, CCL8, PLA2G7, CCL20, TNFRSF11A, CCL5, SLAMF8, CCR1, CCL2, CCL4 |
|
neutrophil migration
GO:1990266
|
17 | 3.40 | 1.6e-04 | S100A9, S100A8, CXCL10, CXCL13, CXCL11, CXCL9, CCL18, CCL8, CXCL3, CCL20, CXCL8, CCL5, TREM1, SLAMF8, CCL2, CCL4, CCR7 |
|
granulocyte chemotaxis
GO:0071621
|
17 | 3.40 | 2.6e-04 | S100A9, S100A8, S100A7, CXCL10, CXCL13, CXCL11, CXCL9, CCL18, CCL8, CXCL3, CCL20, CXCL8, CCL5, TREM1, CCL2, CCL4, CCR7 |
|
granulocyte migration
GO:0097530
|
18 | 3.60 | 6.2e-04 | S100A9, S100A8, S100A7, CXCL10, CXCL13, CXCL11, CXCL9, CCL18, CCL8, CXCL3, CCL20, CXCL8, CCL5, TREM1, SLAMF8, CCL2, CCL4, CCR7 |
|
cytokine-mediated signaling pathway
GO:0019221
|
37 | 7.30 | 1.1e-03 | CXCL10, CXCL13, CXCL11, CXCL9, CCL18, IL1R2, MMP12, CCL8, CXCL3, CCL20, IL12RB2, FOSL1, USP18, CXCL8, ISG15, TNFRSF11A, CCL5, LRP8, MX1, CXCR6, IL2RA, CCR1, STAT1, CCL2, PADI2, RIPK2, IL2RG, CCL4, IFI27, HCK, CCR8, CCR7, LILRB1, BIRC3, IRAK1, AIM2, IL7 |
| Cluster_3 | ||||
|
antimicrobial humoral response
GO:0019730
|
16 | 3.20 | 6.7e-05 | S100A9, S100A7, CXCL10, CXCL13, CXCL11, CAMP, CXCL9, GNLY, CXCL3, LYZ, CXCL8, IGHM, KLK7, PRSS2, H2BC12, SLPI |
|
centromere complex assembly
GO:0034508
|
8 | 1.60 | 1.2e-04 | CENPE, DLGAP5, HJURP, CENPN, CENPI, OIP5, CENPA, CENPF |
|
antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0061844
|
12 | 2.40 | 4.8e-04 | S100A9, S100A7, CXCL10, CXCL13, CXCL11, CAMP, CXCL9, GNLY, CXCL3, CXCL8, KLK7, H2BC12 |
|
response to molecule of bacterial origin
GO:0002237
|
30 | 6.00 | 6.1e-04 | S100A9, S100A8, S100A7, CXCL10, CXCL13, CXCL11, SLC7A5, CAMP, CXCL9, INAVA, IDO1, CXCL3, IL12RB2, MMP9, CXCL8, TNFRSF11A, ASS1, PDCD1LG2, ADM, TNIP3, CCL2, GCH1, RIPK2, HCK, CCR7, LILRB1, SLPI, IL24, IRAK1, CEBPB |
|
response to lipopolysaccharide
GO:0032496
|
29 | 5.80 | 6.2e-04 | S100A9, S100A8, S100A7, CXCL10, CXCL13, CXCL11, SLC7A5, CAMP, CXCL9, IDO1, CXCL3, IL12RB2, MMP9, CXCL8, TNFRSF11A, ASS1, PDCD1LG2, ADM, TNIP3, CCL2, GCH1, RIPK2, HCK, CCR7, LILRB1, SLPI, IL24, IRAK1, CEBPB |
|
humoral immune response
GO:0006959
|
23 | 4.60 | 6.2e-04 | S100A9, S100A7, CXCL10, CXCL13, CXCL11, CAMP, CXCL9, GNLY, CXCL3, LYZ, EXO1, CXCL8, TREM1, C1QB, CCL2, IGHM, C1QA, KLK7, PRSS2, H2BC12, CCR7, SLPI, IL7 |
|
spindle localization
GO:0051653
|
10 | 2.00 | 8.5e-04 | NDC80, ASPM, NUSAP1, MAD2L1, PAX6, PLK1, SPAG5, ESPL1, GPSM2, CENPA |
|
killing of cells of another organism
GO:0031640
|
12 | 2.40 | 1.1e-03 | CAMP, GZMB, GNLY, GBP1, LYZ, NKG7, TREM1, PRF1, PLA2G2A, CLEC7A, GZMA, H2BC12 |
|
disruption of cell in another organism
GO:0141061
|
12 | 2.40 | 1.1e-03 | CAMP, GZMB, GNLY, GBP1, LYZ, NKG7, TREM1, PRF1, PLA2G2A, CLEC7A, GZMA, H2BC12 |
|
regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000079
|
12 | 2.40 | 1.3e-03 | CCNB2, CCNA2, CCNB1, CDKN3, CDC25A, CDC6, PLK1, CCNE1, CCNE2, GTPBP4, BLM, CDKN2A |
| Cluster_4 | ||||
|
negative regulation of cell division
GO:0051782
|
5 | 0.99 | 9.9e-04 | E2F8, ASPM, AURKB, MYC, BLM |
| Cluster_5 | ||||
|
leukocyte cell-cell adhesion
GO:0007159
|
28 | 5.60 | 2.8e-02 | S100A9, S100A8, LAG3, IDO1, ITGB7, ICOS, PLA2G2D, CTLA4, CCL5, TFRC, ASS1, CHST2, LCK, PDCD1LG2, IL2RA, CCL2, SELL, PLA2G2A, HLA-DRB4, HLA-DOB, RIPK2, IL2RG, CCR7, LILRB1, IRAK1, SIRPG, CEBPB, IL7 |
| Cluster_6 | ||||
|
type II interferon production
GO:0032609
|
11 | 2.20 | 4.6e-02 | SLC7A5, IL12RB2, ISG15, PDCD1LG2, TLR8, CD2, CLEC7A, RIPK2, CCR7, LILRB1, CEBPG |
|
regulation of type II interferon production
GO:0032649
|
11 | 2.20 | 4.6e-02 | SLC7A5, IL12RB2, ISG15, PDCD1LG2, TLR8, CD2, CLEC7A, RIPK2, CCR7, LILRB1, CEBPG |
non-Overlap(in control)
dd[["Control_Only"]]@gt_object| Parse form: Control_Only | ||||
| Split into 15 Clusters. Generated by github@zhimingye/EnrichGT | ||||
| Description | Count | PCT | Padj | geneID |
|---|---|---|---|---|
| Cluster_1 | ||||
|
regulation of collagen metabolic process
GO:0010712
|
9 | 1.20 | 0.018 | FAP, CST3, EMILIN1, CBX8, WNT4, TGFB3, UCN, BMP4, MFAP4 |
|
mammary gland morphogenesis
GO:0060443
|
9 | 1.20 | 0.034 | MSX2, ESR1, CAV1, WNT4, GLI3, AR, TBX3, BMP4, PGR |
|
collagen fibril organization
GO:0030199
|
11 | 1.50 | 0.034 | COL3A1, COL5A3, COL5A2, EMILIN1, COL5A1, LOXL1, AEBP1, DPT, FMOD, COL14A1, COMP |
|
collagen biosynthetic process
GO:0032964
|
9 | 1.20 | 0.043 | PCOLCE, P3H3, EMILIN1, COL5A1, CBX8, WNT4, TGFB3, UCN, BMP4 |
|
regulation of protein autophosphorylation
GO:0031952
|
8 | 1.10 | 0.047 | MVP, PRLR, PDGFC, CAV1, EPHA7, ENPP1, PDGFD, ADIPOQ |
|
branching involved in mammary gland duct morphogenesis
GO:0060444
|
6 | 0.83 | 0.050 | MSX2, ESR1, WNT4, AR, TBX3, PGR |
|
ovulation
GO:0030728
|
5 | 0.69 | 0.050 | LEP, MMP2, INHBB, AFP, PGR |
| Cluster_2 | ||||
|
negative regulation of hormone secretion
GO:0046888
|
12 | 1.70 | 0.020 | LEP, INHBB, CCN3, SREBF1, ABCC8, GJA1, IRS1, UCN, CARTPT, ADRA2A, ADIPOQ, CRY2 |
|
protein localization to cilium
GO:0061512
|
10 | 1.40 | 0.050 | ZMYND10, IFT140, BBS1, WDR19, BBS4, DYNC2H1, SPATA7, RABEP1, LZTFL1, ZNF423 |
| Cluster_3 | ||||
|
negative regulation of amyloid-beta formation
GO:1902430
|
6 | 0.83 | 0.035 | SORL1, RTN2, NTRK2, CLU, SPON1, IGF1 |
|
negative regulation of amyloid precursor protein catabolic process
GO:1902992
|
6 | 0.83 | 0.050 | SORL1, RTN2, NTRK2, CLU, SPON1, IGF1 |
non-Overlap(in Test group)
dd[["Test_Only"]]@gt_object| Parse form: Test_Only | ||||
| Split into 15 Clusters. Generated by github@zhimingye/EnrichGT | ||||
| Description | Count | PCT | Padj | geneID |
|---|---|---|---|---|
| Cluster_1 | ||||
|
regulation of mitotic sister chromatid separation
GO:0010965
|
20 | 4.00 | 7.9e-13 | CDCA8, CDC20, NDC80, DLGAP5, UBE2C, MAD2L1, BIRC5, TTK, AURKB, TRIP13, CCNB1, PLK1, BUB1B, ZWINT, SPC25, ESPL1, BUB1, CENPF, FBXO5, ZWILCH |
|
mitotic sister chromatid separation
GO:0051306
|
20 | 4.00 | 1.9e-12 | CDCA8, CDC20, NDC80, DLGAP5, UBE2C, MAD2L1, BIRC5, TTK, AURKB, TRIP13, CCNB1, PLK1, BUB1B, ZWINT, SPC25, ESPL1, BUB1, CENPF, FBXO5, ZWILCH |
|
metaphase/anaphase transition of mitotic cell cycle
GO:0007091
|
23 | 4.60 | 1.8e-11 | CDCA8, CDC20, CENPE, NDC80, DLGAP5, UBE2C, TACC3, MAD2L1, BIRC5, TTK, AURKB, TRIP13, CCNB1, CDC6, PLK1, BUB1B, ZWINT, SPC25, ESPL1, BUB1, CENPF, FBXO5, ZWILCH |
|
metaphase/anaphase transition of cell cycle
GO:0044784
|
23 | 4.60 | 3.1e-11 | CDCA8, CDC20, CENPE, NDC80, DLGAP5, UBE2C, TACC3, MAD2L1, BIRC5, TTK, AURKB, TRIP13, CCNB1, CDC6, PLK1, BUB1B, ZWINT, SPC25, ESPL1, BUB1, CENPF, FBXO5, ZWILCH |
|
negative regulation of sister chromatid segregation
GO:0033046
|
17 | 3.40 | 4.2e-11 | CDCA8, CDC20, NDC80, MAD2L1, BIRC5, TTK, AURKB, TRIP13, CCNB1, PLK1, BUB1B, ZWINT, SPC25, BUB1, CENPF, FBXO5, ZWILCH |
|
negative regulation of mitotic sister chromatid segregation
GO:0033048
|
17 | 3.40 | 4.2e-11 | CDCA8, CDC20, NDC80, MAD2L1, BIRC5, TTK, AURKB, TRIP13, CCNB1, PLK1, BUB1B, ZWINT, SPC25, BUB1, CENPF, FBXO5, ZWILCH |
|
negative regulation of mitotic metaphase/anaphase transition
GO:0045841
|
17 | 3.40 | 4.2e-11 | CDCA8, CDC20, NDC80, MAD2L1, BIRC5, TTK, AURKB, TRIP13, CCNB1, PLK1, BUB1B, ZWINT, SPC25, BUB1, CENPF, FBXO5, ZWILCH |
|
negative regulation of mitotic sister chromatid separation
GO:2000816
|
17 | 3.40 | 4.2e-11 | CDCA8, CDC20, NDC80, MAD2L1, BIRC5, TTK, AURKB, TRIP13, CCNB1, PLK1, BUB1B, ZWINT, SPC25, BUB1, CENPF, FBXO5, ZWILCH |
|
regulation of mitotic metaphase/anaphase transition
GO:0030071
|
22 | 4.40 | 5.3e-11 | CDCA8, CDC20, CENPE, NDC80, DLGAP5, UBE2C, MAD2L1, BIRC5, TTK, AURKB, TRIP13, CCNB1, CDC6, PLK1, BUB1B, ZWINT, SPC25, ESPL1, BUB1, CENPF, FBXO5, ZWILCH |
|
regulation of metaphase/anaphase transition of cell cycle
GO:1902099
|
22 | 4.40 | 8.5e-11 | CDCA8, CDC20, CENPE, NDC80, DLGAP5, UBE2C, MAD2L1, BIRC5, TTK, AURKB, TRIP13, CCNB1, CDC6, PLK1, BUB1B, ZWINT, SPC25, ESPL1, BUB1, CENPF, FBXO5, ZWILCH |
| Cluster_2 | ||||
|
DNA unwinding involved in DNA replication
GO:0006268
|
13 | 2.60 | 1.8e-11 | CDC45, GINS1, GINS2, MCM5, MCM2, HMGA1, RAD51, MCM6, MCM4, GINS4, GINS3, RECQL4, BLM |
|
DNA replication initiation
GO:0006270
|
14 | 2.80 | 3.4e-09 | CDC45, MCM10, CDT1, MCM5, MCM2, CDC6, CCNE1, ORC6, ORC1, CCNE2, MCM6, MCM4, GINS3, GMNN |
|
DNA geometric change
GO:0032392
|
18 | 3.60 | 1.9e-08 | CDC45, TOP2A, GINS1, GINS2, MCM5, MCM2, HMGA1, DSCC1, RAD51, HMGB3, MCM6, MCM4, RFC4, GINS4, GINS3, RECQL4, BLM, DNA2 |
|
DNA duplex unwinding
GO:0032508
|
17 | 3.40 | 4.0e-08 | CDC45, TOP2A, GINS1, GINS2, MCM5, MCM2, HMGA1, DSCC1, RAD51, MCM6, MCM4, RFC4, GINS4, GINS3, RECQL4, BLM, DNA2 |
|
DNA conformation change
GO:0071103
|
18 | 3.60 | 8.0e-08 | CDC45, TOP2A, GINS1, GINS2, MCM5, MCM2, HMGA1, DSCC1, RAD51, HMGB3, MCM6, MCM4, RFC4, GINS4, GINS3, RECQL4, BLM, DNA2 |
|
double-strand break repair via break-induced replication
GO:0000727
|
7 | 1.40 | 3.7e-06 | CDC45, GINS2, MCM5, MCM2, MCM6, MCM4, GINS4 |
|
mitotic DNA replication
GO:1902969
|
8 | 1.60 | 5.2e-06 | CDC45, GINS1, MCM2, RAD51, TK1, MCM6, MCM4, GINS3 |
|
regulation of DNA-templated DNA replication initiation
GO:0030174
|
6 | 1.20 | 3.0e-04 | CDT1, MCM5, MCM2, MCM6, MCM4, GMNN |
|
DNA strand elongation involved in DNA replication
GO:0006271
|
5 | 0.99 | 8.2e-03 | GINS1, MCM4, RFC4, PCNA, DNA2 |
|
telomere organization
GO:0032200
|
14 | 2.80 | 2.6e-02 | NEK2, EZH2, AURKB, EXO1, RAD51, CCNE1, CCNE2, FEN1, CCT5, MYC, PCNA, RECQL4, BLM, DNA2 |
| Cluster_3 | ||||
|
female meiotic nuclear division
GO:0007143
|
10 | 2.00 | 3.1e-06 | CCNB2, NDC80, TOP2A, NCAPH, TTK, TRIP13, AURKA, PLK1, CDC25B, FBXO5 |
|
female meiosis I
GO:0007144
|
6 | 1.20 | 4.9e-05 | CCNB2, NDC80, TRIP13, AURKA, CDC25B, FBXO5 |
|
meiotic cell cycle phase transition
GO:0044771
|
6 | 1.20 | 9.7e-05 | CDC20, CCNB2, NDC80, TTK, CDC25A, CDC25B |
|
DNA replication checkpoint signaling
GO:0000076
|
6 | 1.20 | 3.0e-04 | CDC45, CDT1, CDC6, ORC1, TIPIN, DNA2 |
|
meiotic spindle assembly
GO:0090306
|
5 | 0.99 | 9.9e-04 | CCNB2, NDC80, ASPM, AURKA, FBXO5 |
|
meiotic spindle organization
GO:0000212
|
6 | 1.20 | 1.6e-03 | CCNB2, NDC80, ASPM, AURKA, ESPL1, FBXO5 |
|
serine family amino acid biosynthetic process
GO:0009070
|
5 | 0.99 | 1.1e-02 | PSAT1, PHGDH, CBS, SHMT2, DHFR |
|
liver regeneration
GO:0097421
|
6 | 1.20 | 1.6e-02 | SLC7A5, EZH2, AURKA, TYMS, PCNA, CEBPB |
| Cluster_4 | ||||
|
positive regulation of mitotic sister chromatid separation
GO:1901970
|
7 | 1.40 | 3.1e-05 | CDCA8, CDC20, DLGAP5, UBE2C, BIRC5, AURKB, ESPL1 |
|
regulation of ubiquitin protein ligase activity
GO:1904666
|
6 | 1.20 | 7.5e-04 | CDC20, UBE2C, UBE2S, MAD2L1, PLK1, FBXO5 |
|
mitotic chromosome condensation
GO:0007076
|
5 | 0.99 | 1.4e-02 | NCAPH, NUSAP1, NCAPG, PLK1, NCAPD2 |
|
regulation of ubiquitin-protein transferase activity
GO:0051438
|
6 | 1.20 | 2.6e-02 | CDC20, UBE2C, UBE2S, MAD2L1, PLK1, FBXO5 |
|
chromosome condensation
GO:0030261
|
7 | 1.40 | 2.8e-02 | TOP2A, NCAPH, NUSAP1, CDK1, NCAPG, PLK1, NCAPD2 |
| Cluster_5 | ||||
|
regulation of lymphocyte chemotaxis
GO:1901623
|
7 | 1.40 | 6.2e-04 | S100A7, CXCL10, CXCL13, CCL5, CCL2, PADI2, CCL4 |
|
chronic inflammatory response
GO:0002544
|
6 | 1.20 | 1.6e-03 | S100A9, S100A8, CXCL13, IDO1, CCL5, ADORA2B |
|
T cell chemotaxis
GO:0010818
|
5 | 0.99 | 2.6e-02 | S100A7, CXCL10, CXCL13, CXCL11, CCL5 |
|
eosinophil chemotaxis
GO:0048245
|
5 | 0.99 | 2.6e-02 | CCL18, CCL8, CCL5, CCL2, CCL4 |
| Cluster_6 | ||||
|
tetrahydrofolate metabolic process
GO:0046653
|
5 | 0.99 | 2.5e-03 | MTHFD2, TYMS, GCH1, SHMT2, DHFR |
|
folic acid-containing compound metabolic process
GO:0006760
|
6 | 1.20 | 4.0e-03 | GGH, MTHFD2, TYMS, GCH1, SHMT2, DHFR |
|
pteridine-containing compound metabolic process
GO:0042558
|
6 | 1.20 | 1.3e-02 | GGH, MTHFD2, TYMS, GCH1, SHMT2, DHFR |
| Cluster_7 | ||||
|
positive regulation of type II interferon production
GO:0032729
|
9 | 1.80 | 3.8e-02 | SLC7A5, IL12RB2, ISG15, TLR8, CD2, CLEC7A, RIPK2, LILRB1, CEBPG |
Session Info
sessioninfo::session_info()
#> ─ Session info ───────────────────────────────────────────────────────────────
#> setting value
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#> os macOS 15.0
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#> date 2024-10-12
#> pandoc 3.1.11 @ /Applications/RStudio.app/Contents/Resources/app/quarto/bin/tools/aarch64/ (via rmarkdown)
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#> ──────────────────────────────────────────────────────────────────────────────